Morphological and Bactericidal Effects of Different Antibiotics on Helicobacter pylori

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Morphological and Bactericidal Effects of Different Antibiotics on Helicobacter pylori

BACKGROUND Helicobacter pylori (H. pylori) is a spiral Gram negative bacteria that can transform to the coccoid form in adverse conditions. OBJECTIVES The aim of this study was to determine the in vitro morphological and bactericidal effects of metronidazole, amoxicillin and clarithromycin on H. pylori. MATERIALS AND METHODS The standard strain 26695 of H. pylori was cultured on Brucella ag...

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morphological and bactericidal effects of different antibiotics on helicobacter pylori

conclusions: despite the good in vitro bactericidal effect of amoxicillin on spiral forms of h. pylori, this antibiotic has little effect on induced coccoids that may develop after the inappropriate in vivo antibacterial treatment. hence, for successful therapy, it is essential not only to eradicate the spiral forms, but to eliminate the viable coccoids. background: helicobacter pylori (h. pylo...

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Bactericidal and morphological effects of amoxicillin on Helicobacter pylori.

The growth kinetics of Helicobacter pylori after it has been exposed to amoxicillin have been investigated in conjunction with studies of cell morphology. A potent bactericidal effect was observed at concentrations 10-fold higher than the MIC, but this was accompanied by an increase in the residual numbers of coccoid forms observed. In the presence of 10 micrograms of amoxicillin per ml, these ...

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Bactericidal activity and synergy studies of proton pump inhibitors and antibiotics against Helicobacter pylori in vitro.

The bactericidal activity of the proton pump inhibitors omeprazole and lansoprazole alone and in combination with a beta-lactam or macrolide antibiotic were investigated in vitro. Time-kill curves against Helicobacter pylori NCTC 11637 and a recent clinical isolate revealed significant concentration-dependent killing with all drugs other than amoxycillin. Combinations of proton pump inhibitor a...

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ژورنال

عنوان ژورنال: Jundishapur Journal of Microbiology

سال: 2014

ISSN: 2008-3645,2008-4161

DOI: 10.5812/jjm.8704